Why “Reply All” Can Push All the Wrong Buttons

Bacterial Short Chain Fatty Acids Push All The Buttons Needed To Reactivate Latent Viruses.

The genomes of herpesviruses and HIV become silent during latency through multiple chromatin silencing mechanisms including: histone deacetylation, repressive histone methylation, and DNA methylation. Reactivation of the latent virus requires removal of the chromatin silencing marks and their replacement by activating modifications such as histone acetylation and activating histone methylation....

All models are wrong.

As the field of phylogeography has continued to move in the model-based direction, researchers continue struggling to construct useful models for inference. These models must be both simple enough to be tractable yet contain enough of the complexity of the natural world to make meaningful inference. Beyond constructing such models for inference, researchers explore model space and test competin...

All models are wrong.

A NESTHESIOLOGISTS are master pharmacologists. In the course of our training, we learn that certain types of drugs, the hypnotics, suppress consciousness. We learn that other types of drugs, the analgesics, suppress nociception. Through training and experience, we learn to induce oblivion with judicious combinations of hypnotics and analgesics. We learn to leverage the synergistic interaction o...

Looking in all the wrong places.

Why Clone At All?

Why would anyone clone a sheep or a cow, let alone a human being? None save the genetic determinists who believe an organism is nothing more than the sum total of its genetic makeup and that it is their right to exploit cloned human embryos for spare body parts. Dr. Mae-Wan Ho explains why ‘clone’ is a misnomer. The original Dolly experiment was misguided, and subsequent attempts at cloning man...